Gene Mutation Linked to Type 2 Diabetes
Scientists have identified a unique genetic 2 mutation 3 in about 10 percent of people with type 2 diabetes 4(糖尿病) studied in the United States and Europe. The discovery could help some people learn if they are at risk of developing diabetes so they can seek early treatment and possibly avoid getting the disease altogether.
More than 200 million people worldwide suffer from type 2 diabetes, a potentially fatal disorder 5. The World Health Organization expects diabetes-related deaths to double by 2030. Diabetes strikes people in rich and poor countries alike. World Health Organization statistics show that more than 80% of diabetes deaths occur in low- and middle-income countries. Age and obesity 6 are two risk factors for type 2 diabetes. Another is family history.
"Diabetes is a very important disease that is increasing in every country in the world," says Dr. Ira Goldfine, who has been studying the DNA 7 of people with and without diabetes. "And we need to know what causes it. And we have to get better treatments for it."With type 2 diabetes, the body cannot turn blood sugar into energy. When sugar builds up in the blood, it can lead to serious complications（复杂） including death. That's why people afflicted 8 with the disease need to monitor their blood sugar.
"I have to test my blood virtually every day and make sure that my blood sugar is in a relatively 9 normal range," says Dr. Arthur Lyons was diagnosed with type 2 diabetes three years ago.
It was while studying DNA that Goldfine and his colleagues isolated 10 the genetic mutation.
"We found a protein that’s important, and we found that there are defects of this protein in diabetics," he says.
The gene 1 that makes this protein is called HMGA-1. The protein is important because it is an insulin receptor, which enables insulin to attach to liver cells and converts blood sugar to energy.
"If you don’t have the HMGA-1 gene, then you don’t make the insulin receptor, and if you don’t make the insulin receptor, insulin doesn’t work very effectively," says Goldfine.
Goldfine is one of the co-authors of the study that found the HMGA-1 mutation in some Italian diabetics. The researchers then repeated the finding in American and French patients. All patients were Caucasian. They found that about 10 percent of type 2 diabetics in the United States and Europe, again all Caucasian, have defects in this gene”
"We have a screening test now to identify these people and people who are related to them so we can start treatment and intervention 11 early," says Goldfine.
Early intervention for people with the HMGA-1 mutation including lifestyle changes: getting enough exercise, keeping weight in the normal range and monitoring blood sugar could prevent some people from developing type 2 diabetes. The researchers also say understanding the genetic component 12 of this disease could help doctors provide better treatments to patients with type 2 diabetes, or even one day correct the genetic defect and prevent the disease that way.（本文由在线英语听力室整理编辑）
- A single gene may have many effects.单一基因可能具有很多种效应。
- The targeting of gene therapy has been paid close attention.其中基因治疗的靶向性是值得密切关注的问题之一。
- It's very difficult to treat genetic diseases.遗传性疾病治疗起来很困难。
- Each daughter cell can receive a full complement of the genetic information.每个子细胞可以收到遗传信息的一个完全补偿物。
- People who have this mutation need less sleep than others.有这种突变的人需要的睡眠比其他人少。
- So far the discussion has centered entirely around mutation in the strict sense.到目前为止，严格来讲，讨论完全集中于围绕突变问题上。
- In case of diabetes, physicians advise against the use of sugar.对于糖尿病患者，医生告诫他们不要吃糖。
- Diabetes is caused by a fault in the insulin production of the body.糖尿病是由体內胰岛素分泌失调引起的。
- When returning back,he discovered the room to be in disorder.回家后，他发现屋子里乱七八糟。
- It contained a vast number of letters in great disorder.里面七零八落地装着许多信件。
- One effect of overeating may be obesity.吃得过多能导致肥胖。
- Sugar and fat can more easily lead to obesity than some other foods.糖和脂肪比其他食物更容易导致肥胖。
- DNA is stored in the nucleus of a cell.脱氧核糖核酸储存于细胞的细胞核里。
- Gene mutations are alterations in the DNA code.基因突变是指DNA密码的改变。
- About 40% of the country's population is afflicted with the disease. 全国40%左右的人口患有这种疾病。
- A terrible restlessness that was like to hunger afflicted Martin Eden. 一阵可怕的、跟饥饿差不多的不安情绪折磨着马丁·伊登。
- The rabbit is a relatively recent introduction in Australia.兔子是相对较新引入澳大利亚的物种。
- The operation was relatively painless.手术相对来说不痛。
- His bad behaviour was just an isolated incident. 他的不良行为只是个别事件。
- Patients with the disease should be isolated. 这种病的患者应予以隔离。
- The government's intervention in this dispute will not help.政府对这场争论的干预不会起作用。
- Many people felt he would be hostile to the idea of foreign intervention.许多人觉得他会反对外来干预。