时间:2018-12-24 作者:英语课 分类:2017年Scientific American(一)月


英语课

 


LSD is one of the most potent 1 hallucinogenic drugs—active at just around 100 micrograms…a miniscule amount. That fact has fascinated pharmacologists for decades. Namely, how can it have such long-lasting effects…12 hours or more…at such tiny doses? 


To find out, researchers legally obtained LSD. And built copies of the receptors it binds 2 to in the brain—serotonin receptors. They mixed the LSD and the receptors together, and crystallized the result. They then imaged the structure, using x-ray crystallography.


And they found that when LSD linked up with the serotonin receptor, a sort of "lid" formed over it. Almost like the drug went in, then pulled the door shut behind it. "You could think of the top part of LSD as a hand, holding onto the latch 3 and pulling it down." Bryan Roth, a pharmacologist at University of North Carolina in Chapel 4 Hill involved in the research. 


"This explains why LSD is so potent, why such a small amount of it is active, and secondly 5 why it lasts for such a long period of time. Because basically once it gets in there it takes hours to come off the receptor." The study is in the journal Cell. [Daniel Wacker et al., Crystal Structure of an LSD-Bound Human Serotonin Receptor]


The result may also explain why microdosing—taking even smaller amounts of LSD, at sub-psychedelic levels—might work as a mood enhancer, as some users have reported. "It's clear from the data we have that these small doses can engage these receptors, and of course we know that the receptors that LSD interacts with, they're the same receptors that are thought to be involved in antidepressant drug action." 


Roth does not advocate trying it out. But he says the discovery of the "lid" might someday lead to the development of novel antidepressants—ones with long-lasting effects, at just the tiniest of doses.


—Christopher Intagliata



1 potent
adj.强有力的,有权势的;有效力的
  • The medicine had a potent effect on your disease.这药物对你的病疗效很大。
  • We must account of his potent influence.我们必须考虑他的强有力的影响。
2 binds
v.约束( bind的第三人称单数 );装订;捆绑;(用长布条)缠绕
  • Frost binds the soil. 霜使土壤凝结。 来自《简明英汉词典》
  • Stones and cement binds strongly. 石头和水泥凝固得很牢。 来自《简明英汉词典》
3 latch
n.门闩,窗闩;弹簧锁
  • She laid her hand on the latch of the door.她把手放在门闩上。
  • The repairman installed an iron latch on the door.修理工在门上安了铁门闩。
4 chapel
n.小教堂,殡仪馆
  • The nimble hero,skipped into a chapel that stood near.敏捷的英雄跳进近旁的一座小教堂里。
  • She was on the peak that Sunday afternoon when she played in chapel.那个星期天的下午,她在小教堂的演出,可以说是登峰造极。
5 secondly
adv.第二,其次
  • Secondly,use your own head and present your point of view.第二,动脑筋提出自己的见解。
  • Secondly it is necessary to define the applied load.其次,需要确定所作用的载荷。
学英语单词
absorption reaction rate
abuse of law
acrobatic show
Aleksandrinka
Allo-PBSCT
application workspace
arbitrally
blinking method of stereoscopic viewing
brass watch case blank
Chilean tinamous
cixiid
clap-hand
common laburnum
compartment hot well
compartmentalised
conductivity
contra-cyclical measures
Coquimbo owl
cross platform
cyclotheric sedimentation
dc data set
determinable freeholds
diacetylurea
dicumarols
elasto-aerodynamics
erosional vacuity
erotematic
final thermomechanicaltreatment
Gamu
general most favoured nation clause
glory of the snow
green goodss
gyroso-
hally
haylee
hofners
hydrated stock
hyperthite
idiologism
in the jug
incidental cost
ioduretted
items sample
keep on trucking
kindjals
koevoets
laminated clay
Lasianthus formosensis
leveling off
macro-observation
magmatic circulation
marine windscreen
mGal, mgal
moisture measurer for sand and stone
muscle scars
N.C.
nbcc
nobeliums
nuclenoic
NuLab
on-state characteristic
peritoneal tap
phthioic acid
plate mangle
prends
prevention of collision
prolmon tablet
pyramidal cells
raw mast
reactor coolant system cold leg isolation valve
Regranex
relative-entropy
reliability index of generating system
risto
Rubus chiliadenus
sit down to
solti
standard reference materials
starch ester
static stability margin
stochastic procss
strict secrecy
stupiditarian
superior characters
switching pulse
symbiotic action
synedra undulata
synthetic nitrogenous fertilizer
systematic production of substitution lines
thuggish
total corneal transplantation
total variation decreasing scheme
Tuamarina
twin-screw conveyor
TWTA
ultraviolet radiations
unintentional nonlinearity
unquietous
wassily chair
wax string
y.m