时间:2019-02-03 作者:英语课 分类:英语新闻


英语课

    WASHINGTON, March 4 (Xinhua) -- New data suggest that the epilepsy drug Topamax (topiramate) and its generic 1 versions increase the risk for the birth defects cleft 2 lip(兔唇) and cleft palate in babies born to women who use the medication during pregnancy 3, the U.S. Food and Drug Administration (FDA) said Friday in a statement.

    Before prescribing(规定处方药) topiramate, approved to treat certain types of seizures 4 in people who have epilepsy, health care professionals should warn patients of childbearing age about the potential hazard to the fetus 5 if a woman becomes pregnant while using the drug, the FDA said.

    Topiramate also is approved to prevent migraine headaches, but not to relieve the pain of migraines.

    "Health care professionals should carefully consider the benefits and risks of topiramate when prescribing it to women of childbearing age," said Russell Katz, director of the Division of Neurology Products in the FDA's Center for Drug Evaluation 6 and Research. "Alternative(交流的轮流的) medications that have a lower risk of birth defects should be considered."Cleft lip and cleft palate, collectively called oral clefts 7, are birth defects that occur when parts of the lip or palate do not completely fuse together early in the first trimester of pregnancy, a time when many women do not know they are pregnant.

    The defects range from a small notch 8 in the lip to a groove 9 that runs into the roof of the mouth and nose, possibly leading to problems with eating, talking, and to ear infections. Surgery often is performed to close the lip and palate and most children do well after treatment.

    Data from the North American Antiepileptic Drug (AED) Pregnancy Registry indicate an increased risk of oral clefts in infants exposed to topiramate during the first trimester of pregnancy. Infants exposed to topiramate as a single therapy experienced a 1.4 percent prevalence of oral clefts, compared with a prevalence of 0.38 percent - 0.55 percent in infants exposed to other antiepileptic drugs.

    Infants of mothers who did not have epilepsy and were not being treated with other antiepileptic drugs had a prevalence of 0.07 percent. Similar data from the United Kingdom Epilepsy and Pregnancy Register supported the North American AED Pregnancy Registry data.

    According to the FDA, before starting topiramate, pregnant women and women of childbearing potential should discuss other treatment options with their health care professional.(本文由在线英语听力室整理编辑)



adj.一般的,普通的,共有的
  • I usually buy generic clothes instead of name brands.我通常买普通的衣服,不买名牌。
  • The generic woman appears to have an extraordinary faculty for swallowing the individual.一般妇女在婚后似乎有特别突出的抑制个性的能力。
n.裂缝;adj.裂开的
  • I hid the message in a cleft in the rock.我把情报藏在石块的裂缝里。
  • He was cleft from his brother during the war.在战争期间,他与他的哥哥分离。
n.怀孕,怀孕期
  • Early pregnancy is often accompanied by nausea.怀孕早期常有恶心的现象。
  • Smoking during pregnancy increases the risk of miscarriage.怀孕期吸烟会增加流产的危险。
n.起获( seizure的名词复数 );没收;充公;起获的赃物
  • Seizures of illicit drugs have increased by 30% this year. 今年违禁药品的扣押增长了30%。 来自《简明英汉词典》
  • Other causes of unconsciousness predisposing to aspiration lung abscess are convulsive seizures. 造成吸入性肺脓肿昏迷的其他原因,有惊厥发作。 来自辞典例句
n.胎,胎儿
  • In the fetus,blood cells are formed in different sites at different ages.胎儿的血细胞在不同时期生成在不同的部位。
  • No one knows why a fetus is not automatically rejected by the mother's immune system. 没有人知道为什么母亲的免疫系统不会自动排斥胎儿。
n.估价,评价;赋值
  • I attempted an honest evaluation of my own life.我试图如实地评价我自己的一生。
  • The new scheme is still under evaluation.新方案还在评估阶段。
n.裂缝( cleft的名词复数 );裂口;cleave的过去式和过去分词;进退维谷
  • Clefts are often associated with other more serious congenital defects. 裂口常与其他更严重的先天性异常并发。 来自辞典例句
  • Correction of palate clefts is much more difficult and usually not as satisfactory. 硬腭裂的矫正更为困难,且常不理想。 来自辞典例句
n.(V字形)槽口,缺口,等级
  • The peanuts they grow are top-notch.他们种的花生是拔尖的。
  • He cut a notch in the stick with a sharp knife.他用利刃在棒上刻了一个凹痕。
n.沟,槽;凹线,(刻出的)线条,习惯
  • They're happy to stay in the same old groove.他们乐于墨守成规。
  • The cupboard door slides open along the groove.食橱门沿槽移开。
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